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Detoxification enzymes in the duodenal mucosa of patients with familial adenomatous polyposis
(p.754-755)
M. Berkhout, H. M. J. Roelofs, P. Friederich, J. H. J. M. van Krieken, F. M. Nagengast, W. H. M. Peters
allan spigelman,
,
Australia
July 14, 2005
This short note discounted an effect of some detoxification enzymes on duodenal polyposis in patients with familial adenomatous polyposis (FAP). The conclusion reached, namely that these detoxification enzymes are unlikely to be involved in duodenal adenomatosis in FAP should have read "these detoxification enzymes in the duodenal mucosa are unlikely ...".
As well as the established high risk for duodenal polyposis and cancers, particularly around the ampulla of Vater in FAP, there exists a high risk for cancer throughout the hepatobiliary tract. Moreover, when surgical reimplantation is performed, new polyps occur around the neoampulla. Possible explanations include abnormal hepatic metabolism of carcinogens (modulated by detoxification enzymes) and / or hypersensitivity of the mucosa, perhaps as a result of the loss of the APC gene product, to bile.
A Spigelman
John Hunter Hospital, University of Newcastle, Newcastle 2291, Australia
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