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Association of visceral adiposity with oesophageal and junctional adenocarcinomas. BJS 2010; 97: 1028-1034.

Published: 14th May 2010

Authors: P. Beddy, J. Howard, C. McMahon, M. Knox, C. de Blacam, N. Ravi et al.

Background

Obesity is associated with an increased incidence of oesophageal and oesophagogastric junction adenocarcinoma, in particular Siewert types I and II. This study compared abdominal fat composition in patients with oesophageal/junctional adenocarcinoma with that in patients with oesophageal squamous cell carcinoma and gastric adenocarcinoma, and in controls.

Results

Patients with oesophageal/junctional adenocarcinoma had significantly higher TFA and VFA values compared with controls (both P < 0·001), patients with gastric adenocarcinoma (P = 0·013 and P = 0·006 respectively) and patients with oesophageal squamous cell carcinoma (both P < 0·001). For junctional tumours, the highest TFA and VFA values were seen in patients with Siewert type I tumours (respectively P = 0·041 and P = 0·033 versus type III; P = 0·332 and P = 0·152 versus type II).

Conclusion

Patients with oesophageal/junctional adenocarcinoma, in particular oesophageal and Siewert type I junctional tumours, have greater CT‐defined visceral adiposity than patients with gastric adenocarcinoma or oesophageal squamous cell carcinoma, or controls. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

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