Cardiovascular and all‐cause mortality in patients with intermittent claudication and critical limb ischaemia.
Published: 8th November 2017
Authors: S. T. W. van Haelst, C. Koopman, H. M. den Ruijter, F. L. Moll, F. L. Visseren, I. Vaartjes et al.
The aim of this study was to evaluate absolute mortality risks and to determine whether changes in mortality risk occurred in patients with intermittent claudication (IC) or critical limb ischaemia (CLI) in the Netherlands between 1998 and 2010.
Data for patients treated between 1998 and 2010 were obtained from Dutch nationwide registers: the Hospital Discharge Register, Population Register and Cause of Death Register. The registers were used to obtain information regarding IC and CLI hospitalizations, co‐morbidities, demographic factors, and date and cause of death. The cohort was split into two time intervals for comparison: 1998–2004 (period 1) and 2005–2010 (period 2). Thirty‐day mortality was excluded to eliminate per‐admission complications. One‐ and 5‐year cardiovascular and all‐cause mortality rates were compared with those of a representative sample of the general Dutch population (28 494 persons) by Cox proportional hazards models.
Some 47 548 patients were included, 34 078 with IC and 13 470 with CLI. In patients with IC, the age‐adjusted 5‐year mortality risk for cardiovascular disease decreased significantly in period 2 (14·1 per cent) compared with that in period 1 (16·1 per cent) in men only (5‐year adjusted hazard ratio (HR) 0·76, 95 per cent c.i. 0·69 to 0·83;
The risk of premature death in patients with IC and CLI declined significantly in the Netherlands, in a sex‐specific manner, over the period from 1998 to 2010. The absolute risk of cardiovascular mortality remains high in these patients.Read more
You may also be interested in
Authors: M. Kanapathy, R. Simpson, L. Madden, C. Thrasivoulou, A. Mosahebi, D. L. Becker et al.
Notes: Potential marker of disease severity
Meta‐analysis of the association between peripheral artery disease and growth of abdominal aortic aneurysms. BJS 2017; 104: 1765-1774.
Authors: E. O. Matthews, S. E. Rowbotham, J. V. Moxon, R. E. Jones, M. Vega de Ceniga, J. Golledge et al.
Notes: No significant association
Randomized feasibility trial of high‐intensity interval training before elective abdominal aortic aneurysm repair. BJS 2017; 104: 1791-1801.
Authors: G. A. Tew, A. M. Batterham, K. Colling, J. Gray, K. Kerr, E. Kothmann et al.
Notes: Precursor to a bigger trial
Meta‐analysis of the association between alcohol consumption and abdominal aortic aneurysm. BJS 2017; 104: 1756-1764.
Authors: S. M. Spencer, A. J. Trower, X. Jia, D. J. A. Scott, D. C. Greenwood
Notes: Small increase above 2 units/day
Meta‐analysis of the costs of carotid artery stenting and carotid endarterectomy. BJS 2017; 104: 1284-1292.
Authors: E. E. de Vries, V. G. M. Baldew, H. M. den Ruijter, G. J. de Borst
Systematic review of patient‐reported outcome measures in patients with varicose veins. BJS 2017; 104: 1424-1432.
Authors: A. Aber, E. Poku, P. Phillips, M. Essat, H. Buckley Woods, S. Palfreyman et al.
Notes: AVVQ and SF‐36 good options
Authors: T. R. A. Lane, L. Varatharajan, F. Fiorentino, A. C. Shepherd, L. Zimmo, M. S. Gohel et al.
Notes: Unreliable predictor of disease severity and PROMs
Sex differences in mortality after abdominal aortic aneurysm repair in the UK. BJS 2017; 104: 1656-1664.
Authors: D. A. Sidloff, A. Saratzis, M. J. Sweeting, J. Michaels, J. T. Powell, S. G. Thompson et al.
Notes: Mortality double in women
Time‐dependent trends in cardiovascular adverse events during follow‐up after carotid or iliofemoral endarterectomy. BJS 2017; 104: 1477-1485.
Authors: I. D. van Koeverden, S. T. W. van Haelst, S. Haitjema, J.‐P. P. M. de Vries, F. L. Moll, H. M. den Ruijter et al.
Notes: No decline in events
Association between metformin prescription and growth rates of abdominal aortic aneurysms. BJS 2017; 104: 1486-1493.
Authors: J. Golledge, J. Moxon, J. Pinchbeck, G. Anderson, S. Rowbotham, J. Jenkins et al.
Notes: Worth an RCT
Systematic review of carotid artery procedures and the volume–outcome relationship in Europe. BJS 2017; 104: 1273-1283.
Authors: P. Phillips, E. Poku, M. Essat, H. B. Woods, E. A. Goka, E. C. Kaltenthaler et al.
Notes: More justification for higher‐volume centres
Systematic review of mortality risk prediction models in the era of endovascular abdominal aortic aneurysm surgery. BJS 2017; 104: 964-976.
Authors: N. Lijftogt, T. W. F. Luijnenburg, A. C. Vahl, E. D. Wilschut, V. J. Leijdekkers, M. F. Fiocco et al.
Notes: No more please