Clinical assessment to determine the risk of bowel cancer using Symptoms, Age, Mass and Iron deficiency anaemia (SAMI). BJS 2017; 104: 1393-1404.
Published: 21st June 2017
Authors: M. R. Thompson, D. P. O'Leary, K. Flashman, A. Asiimwe, B. G. Ellis, A. Senapati et al.
The aim of this study was to identify characteristics with independent predictive value for bowel cancer for use in the clinical assessment of patients attending colorectal outpatient clinics.
This was a 22‐year (1986–2007) retrospective cohort analysis of data collected prospectively from patients who attended colorectal surgical outpatient clinics in Portsmouth. The data set was split randomly into two groups of patients to generate and validate a predictive model. Multivariable logistic regression was used to create and validate a system to predict outcome. Receiver operating characteristic (
Data from 29 005 patients were analysed. Discrimination of the model for bowel cancer was high in the development (C‐statistic 0·87, 95 per cent c.i. 0·85 to 0·88) and validation (C‐statistic 0·86, 0·84 to 0·87) groups. The most important co‐variables in the final model were: age (
A clinical assessment that systematically identifies or excludes four symptom–age combinations, a mass and
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