Effect of age on rates of palliative surgery and chemotherapy use in patients with locally advanced or metastatic gastric cancer. BJS 2017; 104: 1837-1846.
Published: 9th August 2017
Authors: S. D. Nelen, M. van Putten, V. E. P. P. Lemmens, K. Bosscha, J. H. W. de Wilt, R. H. A. Verhoeven et al.
This study assessed trends in the treatment and survival of palliatively treated patients with gastric cancer, with a focus on age‐related differences.
For this retrospective, population‐based, nationwide cohort study, all patients diagnosed between 1989 and 2013 with non‐cardia gastric cancer with metastasized disease or invasion into adjacent structures were selected from the Netherlands Cancer Registry. Trends in treatment and 2‐year overall survival were analysed and compared between younger (age less than 70 years) and older (aged 70 years or more) patients. Analyses were done for five consecutive periods of 5 years, from 1989–1993 to 2009–2013. Multivariable logistic regression analysis was used to examine the probability of undergoing surgery. Multivariable Cox regression analysis was used to identify independent risk factors for death.
Palliative resection rates decreased significantly in both younger and older patients, from 24·5 and 26·2 per cent to 3·0 and 5·0 per cent respectively. Compared with patients who received chemotherapy alone, both younger (21·6
Despite changes in the use of resection and chemotherapy as palliative treatment, overall survival rates of patients with advanced and metastatic gastric cancer did not improve.Read more
You may also be interested in
Comparison of gaze behaviour of trainee and experienced surgeons during laparoscopic gastric bypass.
Authors: S. Erridge, H. Ashraf, S. Purkayastha, A. Darzi, M. H. Sodergren
Notes: Potential uses in training and assessment
Impact of weight loss and eating difficulties on health‐related quality of life up to 10 years after oesophagectomy for cancer.
Authors: P. Anandavadivelan, A. Wikman, A. Johar, P. Lagergren
Notes: Associated with deterioration of HRQOL
Influence of national centralization of oesophagogastric cancer on management and clinical outcome from emergency upper gastrointestinal conditions.
Authors: S. R. Markar, H. Mackenzie, T. Wiggins, A. Askari, A. Karthikesalingam, O. Faiz et al.
Notes: Improves outcome of oesophageal perforation
Meta‐analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer.
Authors: K. Polom, L. Marano, D. Marrelli, R. De Luca, G. Roviello, V. Savelli et al.
Notes: Microsatellite instability subgroup does better
Authors: V. Wanjura, E. Szabo, J. Österberg, J. Ottosson, L. Enochsson, G. Sandblom et al.
Notes: Avoid unnecessary surgery
Authors: J. Deng, J. Guo, G. Ma, H. Zhang, D. Sun, Y. Hou et al.
Notes: Identifies a poor prognosis group
Meta‐analysis of the impact of surgical approach on the grade of mesorectal excision in rectal cancer. BJS 2017; 104: 1609-1619.
Authors: B. Creavin, M. E. Kelly, E. Ryan, D. C. Winter
Notes: Open excision provides better‐quality mesorectum
Multicentre cohort study to define and validate pathological assessment of response to neoadjuvant therapy in oesophagogastric adenocarcinoma. BJS 2017; 104: 1816-1828.
Authors: F. Noble, M. A. Lloyd, R. Turkington, E. Griffiths, M. O'Donovan, J. R. O'Neill et al.
Notes: Response associated with survival
Authors: P. Probst, S. Ohmann, U. Klaiber, F. J. Hüttner, A. T. Billeter, A. Ulrich et al.
Notes: Publication bias likely
Randomized clinical trial
Double‐blind randomized clinical trial of percutaneous endoscopic gastrostomy versus radiologically inserted gastrostomy in children. BJS 2017; 104: 1620-1627.
Authors: R. R. Singh, S. A. Nah, D. J. Roebuck, S. Eaton, A. Pierro, J. I. Curry et al.
Notes: No difference in the number or magnitude of complications
Weekend admission and mortality for gastrointestinal disorders across England and Wales. BJS 2017; 104: 1723-1734.
Authors: S. E. Roberts, T. H. Brown, K. Thorne, R. A. Lyons, A. Akbari, D. J. Napier et al.
Notes: Worst for gastrointestinal cancer and liver disease
Use of endoscopy to determine the resection margin during laparoscopic gastrectomy for cancer. BJS 2017; 104: 1829-1836.
Authors: S. Kawakatsu, M. Ohashi, N. Hiki, S. Nunobe, M. Nagino, T. Sano et al.