Feasibility of reirradiation in the treatment of locally recurrent rectal cancer. BJS 2014; 101: 1280-1289.
Published: 22nd July 2014
Authors: S. J. Bosman, F. A. Holman, G. A. P. Nieuwenhuijzen, H. Martijn, G.‐J. Creemers, H. J. T. Rutten et al.
Many patients with locally recurrent rectal cancer receive radiotherapy for the treatment of the primary tumour. It is unclear whether reirradiation is safe and effective when a local recurrence develops. The aim of this study was to evaluate the toxicity and oncological outcome of reirradiation in patients with locally recurrent rectal carcinoma.
From March 1994 until December 2013, data on patients with locally recurrent rectal cancer (without distant metastasis) were entered into a database. Patients were reirradiated with a reduced dose of 30 Gy and received an intraoperative electron radiotherapy boost during surgery. Morbidity associated with radiotherapy, postoperative complications and oncological outcome were evaluated.
Clear margins (
Reirradiation (with concomitant chemotherapy) has few side‐effects and complements radical resection of recurrent rectal cancer.Full text
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