Functional mucous layer and healing of proximal colonic anastomoses in an experimental model. BJS 2017; 104: 619-630.
Published: 13th February 2017
Authors: J. W. A. M. Bosmans, A. C. H. M. Jongen, G. M. H. Birchenough, E. E. L. Nyström, M. J. J. Gijbels, J. P. M. Derikx et al.
Anastomotic leakage (
Mice of different Muc2 genotypes were used in a proximal colonic
Of 22 Muc2‐deficient (Muc2−/−) mice, 20 developed
A functional mucous layer facilitates the healing of colonic anastomoses. Colorectal anastomotic leakage remains the most dreaded complication after colorectal surgery. It is known that the aetiology of anastomotic leakage is multifactorial, and a role is suggested for the interaction between intraluminal content and mucosa.
Colorectal anastomotic leakage remains the most dreaded complication after colorectal surgery. It is known that the aetiology of anastomotic leakage is multifactorial, and a role is suggested for the interaction between intraluminal content and mucosa.Full text
You may also be interested in
Oncological outcome after MRI‐based selection for neoadjuvant chemoradiotherapy in the OCUM Rectal Cancer Trial.
Authors: R. Ruppert, T. Junginger, H. Ptok, J. Strassburg, C. A. Maurer, P. Brosi et al.
Notes: Limiting radiotherapy appears safe.
Randomized clinical trial
Randomized clinical trial of elective resection versus observation in diverticulitis with extraluminal air or abscess initially managed conservatively.
Authors: K. You, R. Bendl, C. Taut, R. Sullivan, M. Gachabayov, R. Bergamaschi et al.
Notes: Conservative management appropriate
Authors: E. Duchalais, T. Glyn Mullaney, G. M. Spears, S. R. Kelley, K. Mathis, W. S. Harmsen et al.
Notes: Post‐treatment T stage predicts prognosis
Nationwide trends in the incidence and outcome of patients with gastrointestinal stromal tumour in the imatinib era.
Authors: W. T. A. van der Graaf, R. Tielen, J. J. Bonenkamp, V. Lemmens, R. H. A. Verhoeven, J. H. W. de Wilt et al.
Notes: Surgery improves survival
Prognostic impact of perihepatic lymph node metastases in patients with resectable colorectal liver metastases.
Authors: M. Okuno, C. Goumard, T. Mizuno, S. Kopetz, K. Omichi, C.‐W. D. Tzeng et al.
Notes: Bad sign of advanced disease
Authors: F. Ris, E. Liot, N. C. Buchs, R. Kraus, G. Ismael, V. Belfontali et al.
Notes: Appears to reduce leaks
Novel de novo synthesized phosphate carrier compound ABA‐PEG20k‐Pi20 suppresses collagenase production in Enterococcus faecalis and prevents colonic anastomotic leak in an experimental model.
Authors: M. Wiegerinck, S. K. Hyoju, J. Mao, A. Zaborin, C. Adriaansens, E. Salzman et al.
Notes: Further evidence the microbiome may be important
Systematic review of the influence of socioeconomic deprivation on mortality after colorectal surgery.
Authors: T. E. Poulton, T. Salih, P. Martin, A. Rojas‐Garcia, R. Raine, S. R. Moonesinghe et al.
Notes: Major differences in mortality
Two‐year results of the randomized clinical trial DILALA comparing laparoscopic lavage with resection as treatment for perforated diverticulitis.
Authors: A. Kohl, J. Rosenberg, D. Bock, T. Bisgaard, S. Skullman, A. Thornell et al.
Notes: Laparoscopic lavage still an option
Hyperactive cyclic motor activity in the distal colon after colonic surgery as defined by high‐resolution colonic manometry. BJS 2018; 105: 907-917.
Authors: R. Vather, G. O'Grady, A. Y. Lin, P. Du, C. I. Wells, D. Rowbotham et al.
Notes: May contribute to gut dysfunction
Progress and future direction in the management of advanced colorectal cancer. BJS 2018; 105: 615-617.
Authors: K. G. M. Brown, M. J. Solomon
Authors: S. Yamashita, Y. S. Chun, S. E. Kopetz, J.‐N. Vauthey
Notes: Molecular influences on outcome