Intra‐anal and rectal application of L‐erythro methoxamine gel increases anal resting pressure in healthy volunteers. BJS 2005; 92: 1539-1545.
Published: 17th October 2005
Authors: P. J. Nisar, H.‐J. Gruss, D. Bush, N. Barras, A. G. Acheson, J. H. Scholefield et al.
This study examined the effect of a single local application of
Perianal gel produced no increase in MARP. Intra‐anal 1 per cent and 3 per cent gel produced a significant rapid rise in MARP for 4 and 5 h respectively after application (P = 0·012 and P = 0·017 respectively). Rectal 1 per cent gel increased MARP for 2 h after application (P = 0·036). Intra‐anal gel resulted in an increase in systolic blood pressure (1 per cent gel at 2 h, P = 0·042; 3 per cent gel at 4 h, P = 0·017). One per cent intra‐anal and rectal gels caused a decrease in the pulse rate for 2 h after application (P = 0·012 and P = 0·018 respectively). Six subjects complained of nausea and three of headache after gel application.
Intra‐anal and rectal gel produced a sustained rise in MARP with rapid onset in volunteers. This raises the possibility of a therapeutic application for