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Meta‐analysis of contemporary short‐ and long‐term mortality rates in patients diagnosed with critical leg ischaemia. BJS 2013; 100: 1002-1008.

Published: 3rd May 2013

Authors: K. E. Rollins, D. Jackson, P. A. Coughlin


Critical leg ischaemia (CLI) has been associated with high mortality rates. There is a lack of contemporary data on both short‐ and long‐term mortality rates in patients diagnosed with CLI.


This was a systematic literature search for studies prospectively reporting mortality in patients diagnosed with CLI. Meta‐analysis and meta‐regression models were developed to determine overall mortality rates and specific patient‐related factors that were associated with death.


A total of 50 studies were included in the analysis The estimated probability of all‐cause mortality in patients with CLI was 3·7 per cent at 30 days, 17·5 per cent at 1 year, 35·1 per cent at 3 years and 46·2 per cent at 5 years. Men had a statistically significant survival benefit at 30 days and 3 years. The presence of ischaemic heart disease, tissue loss and older age resulted in a higher probability of death at 3 years.


Early mortality rates in patients diagnosed with CLI have improved slightly compared with previous historical data, but long‐term mortality rates are still high.

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