Meta‐analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer. BJS 2018; 105: 946-958.
Published: 30th April 2018
Authors: E. Versteijne, J. A. Vogel, M. G. Besselink, O. R. C. Busch, J. W. Wilmink, J. G. Daams et al.
Studies comparing upfront surgery with neoadjuvant treatment in pancreatic cancer may report only patients who underwent resection and so survival will be skewed. The aim of this study was to report survival by intention to treat in a comparison of upfront surgery
MEDLINE, Embase and the Cochrane Library were searched for studies reporting median overall survival by intention to treat in patients with resectable or borderline resectable pancreatic cancer treated with or without neoadjuvant treatment. Secondary outcomes included overall and R0 resection rate, pathological lymph node rate, reasons for unresectability and toxicity of neoadjuvant treatment.
In total, 38 studies were included with 3484 patients, of whom 1738 (49·9 per cent) had neoadjuvant treatment. The weighted median overall survival by intention to treat was 18·8 months for neoadjuvant treatment and 14·8 months for upfront surgery; the difference was larger among patients whose tumours were resected (26·1
Neoadjuvant treatment appears to improve overall survival by intention to treat, despite lower overall resection rates for resectable or borderline resectable pancreatic cancer.Full text
You may also be interested in
Meta‐analysis of the influence of lifestyle changes for preoperative weight loss on surgical outcomes.
Authors: M. Roman, A. Monaghan, G. F. Serraino, D. Miller, S. Pathak, F. Lai et al.
Notes: Possible but how much is enough?
Cost‐effectiveness of liver transplantation in patients with colorectal metastases confined to the liver.
Authors: G. M. W. Bjørnelv, S. Dueland, P.‐D. Line, P. Joranger, Å. A. Fretland, B. Edwin et al.
Notes: Not for every country
Multicentre cohort study of antihypertensive and lipid‐lowering therapy cessation after bariatric surgery.
Authors: J. Thereaux, T. Lesuffleur, S. Czernichow, A. Basdevant, S. Msika, D. Nocca et al.
Notes: Better than controls
Authors: M. S. de Vos, J. F. Hamming
Development and validation of a nomogram to predict recurrence and melanoma‐specific mortality in patients with negative sentinel lymph nodes.
Authors: D. Verver, D. van Klaveren, V. Franke, A. C. J. van Akkooi, P. Rutkowski, U. Keilholz et al.
Notes: Could personalize care
Authors: A. M. Warwick, T. Jenks, R. Fisher, R. Garrett‐Cox, F. Lecky, D. Yates et al.
Notes: Better in hospitals with a paediatric surgeon
Experimental study of needle recording electrodes placed on the thyroid cartilage for neuromonitoring during thyroid surgery.
Authors: Y. Zhao, C. Li, D. Zhang, L. Zhou, X. Liu, S. Li et al.
Notes: Quick and stable
Authors: D. J. Harris, S. J. Vine, M. R. Wilson, J. S. McGrath, M.‐E. LeBel, G. Buckingham et al.
Notes: Watching other surgeons helpful
Mitochondrial function after associating liver partition and portal vein ligation for staged hepatectomy in an experimental model.
Authors: A. Budai, G. Horváth, L. Tretter, Z. Radák, E. Koltai, Z. Bori et al.
Notes: Defines the biochemical basis
Authors: A. Storesund, A. S. Haugen, M. Hjortås, M. W. Nortvedt, H. Flaatten, G. E. Eide et al.
Notes: Code correctly