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Meta‐analysis of adjuvant chemotherapy after radical surgery for advanced gastric cancer. BJS 2009; 96: 26-33.

Published: 17th November 2008

Authors: P. Sun, J.‐B. Xiang, Z.‐Y. Chen

Background

There is no consensus of opinion about postoperative adjuvant chemotherapy after radical surgery for advanced gastric cancer. This is a meta‐analysis of the published results of relevant randomized clinical trials (RCTs).

Method

Electronic databases from January 1998 to December 2007 were searched and 12 RCTs were selected. These included a total of 3809 patients. The hazard ratio (HR) for overall survival was calculated.

Results

The pooled HR for overall survival was 0·78 (95 per cent confidence interval 0·71 to 0·85) in favour of chemotherapy. Subgroup analysis showed that the advantage of chemotherapy was not influenced by depth of tumour infiltration, status of lymph node metastasis, type of lymphadenectomy, geographical distribution of patients or route of drug administration.

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