MiR‐128 regulation of glucose metabolism and cell proliferation in triple‐negative breast cancer. BJS 2018; 105: 75-85.
Published: 8th November 2017
Authors: M. Xiao, C. Lou, H. Xiao, Y. Yang, X. Cai, C. Li et al.
Triple‐negative breast cancer (TNBC) is prone to metastasis and has a poor prognosis, with lower survival rates than other breast cancer subtypes. MicroRNAs have recently emerged as powerful regulators of cancer processes and become a promising target in cancer therapy.
Expression of miR‐128 was examined in invasive ductal breast cancer, and its relationship with clinicopathological features analysed. A series of
A cohort of 110 women with TNBC and 117 with non‐TNBC were included in the study. In multivariable Cox regression analysis, overall and disease‐free survival were significantly associated with lymph node metastasis, histological grade and molecular subtype. Subgroup analysis showed that low expression of miR‐128 correlated with shorter overall and disease‐free survival in TNBC (
MiR‐128 might be a prognostic marker and possible molecular target for therapy in patients with TNBC.Full text
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