Modalities for image‐ and molecular‐guided cancer surgery. BJS 2018; 105: e69-e83.
Published: 17th January 2018
Authors: M. A. Stammes, S. L. Bugby, T. Porta, K. Pierzchalski, T. Devling, C. Otto et al.
Surgery is the cornerstone of treatment for many solid tumours. A wide variety of imaging modalities are available before surgery for staging, although surgeons still rely primarily on visual and haptic cues in the operating environment. Image and molecular guidance might improve the adequacy of resection through enhanced tumour definition and detection of aberrant deposits. Intraoperative modalities available for image‐ and molecular‐guided cancer surgery are reviewed here.
Intraoperative cancer detection techniques were identified through a systematic literature search, with selection of peer‐reviewed publications from January 2012 to January 2017. Modalities were reviewed, described and compared according to 25 predefined characteristics. To summarize the data in a comparable way, a three‐point rating scale was applied to quantitative characteristics.
The search identified ten image‐ and molecular‐guided surgery techniques, which can be divided into four groups: conventional, optical, nuclear and endogenous reflectance modalities. Conventional techniques are the most well known imaging modalities, but unfortunately have the drawback of a defined resolution and long acquisition time. Optical imaging is a real‐time modality; however, the penetration depth is limited. Nuclear modalities have excellent penetration depth, but their intraoperative use is limited by the use of radioactivity. Endogenous reflectance modalities provide high resolution, although with a narrow field of view.
Each modality has its strengths and weaknesses; no single technique will be suitable for all surgical procedures. Strict selection of modalities per cancer type and surgical requirements is required as well as combining techniques to find the optimal balance.Full text
You may also be interested in
Short‐term medical treatment of hypercalcaemia in primary hyperparathyroidism predicts symptomatic response after parathyroidectomy.
Authors: A. Koman, S. Ohlsson, R. Bränström, Y. Pernow, R. Bränström, I.‐L. Nilsson et al.
Excision of both pretreatment marked positive nodes and sentinel nodes improves axillary staging after neoadjuvant systemic therapy in breast cancer.
Authors: J. M. Simons, M. L. M. A. van Pelt, A. W. K. S. Marinelli, M. E. Straver, A. M. Zeillemaker, L. M. Pereira Arias‐Bouda et al.
Development and evaluation of the General Surgery Objective Structured Assessment of Technical Skill (GOSATS).
Authors: Y. Halwani, A. K. Sachdeva, L. Satterthwaite, S. de Montbrun
Randomized controlled trial of plain English and visual abstracts for disseminating surgical research via social media.
Authors: S. J. Chapman, R. C. Grossman, M. E. B. FitzPatrick, R. R. W. Brady
Authors: H. K. James, A. W. Chapman, G. T. R. Pattison, D. R. Griffin, J. D. Fisher
Network meta‐analysis of urinary retention and mortality after Lichtenstein repair of inguinal hernia under local, regional or general anaesthesia.
Authors: J. H. H. Olsen, S. Öberg, K. Andresen, T. W. Klausen, J. Rosenberg
Effect of donor nephrectomy time during circulatory‐dead donor kidney retrieval on transplant graft failure.
Authors: L. Heylen, J. Pirenne, U. Samuel, I. Tieken, M. Coemans, M. Naesens et al.
Dysregulation of the actin scavenging system and inhibition of DNase activity following severe thermal injury.
Authors: R. J. Dinsdale, J. Hazeldine, K. Al Tarrah, P. Hampson, A. Devi, C. Ermogenous et al.
Authors: C. A. Sewalt, E. Venema, E. J. A. Wiegers, F. E. Lecky, S. C. E. Schuit, D. den Hartog et al.
Authors: L. Cairncross, H. A. Snow, D. C. Strauss, M. J. F. Smith, O. Sjokvist, C. Messiou et al.
Authors: L. Scholten, T. F. Stoop, M. Del Chiaro, O. R. Busch, C. van Eijck, I. Q. Molenaar et al.