Normothermic machine perfusion for the assessment and transplantation of declined human kidneys from donation after circulatory death donors.
Published: 6th December 2017
Authors: S. A. Hosgood, E. Thompson, T. Moore, C. H. Wilson, M. L. Nicholson
A significant proportion of donation after circulatory death (DCD) kidneys are declined for transplantation because of concerns over their quality.
In phase 1 of this study, declined human DCD kidneys underwent NMP assessment for 60 min. Kidneys were graded 1–5 using a quality assessment score (QAS) based on macroscopic perfusion, renal blood flow and urine output during NMP. In phase 2 of the study, declined DCD kidneys were assessed by NMP with an intention to transplant them.
In phase 1, 18 of 42 DCD kidneys were declined owing to poor
NMP technology can be used to increase the number of DCD kidney transplants by assessing their quality before transplantation.Read more
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