Patient‐reported outcomes in long‐term survivors of metastatic colorectal cancer needing liver resection.
Published: 19th August 2014
Authors: J. R. Rees, J. M. Blazeby, S. T. Brookes, T. John, F. K. Welsh, M. Rees et al.
Five‐year survival after hepatic resection for colorectal cancer (
The study used the European Organization for Research and Treatment of Cancer (
A total of 241 patients were recruited; nine (3·7 per cent) had unresectable disease and were excluded. Some 68 (42 men) of 80 long‐term survivors participated; their mean age was 69·5 years and median follow‐up was 8·0 (range 6·9–9·2) years. Values for baseline and 1‐year patient‐reported outcome data were similar. Scores for functional scales were excellent (emotional function: 92, 95 per cent c.i. 87 to 96; social function: 94, 89 to 99; role function: 94, 90 to 98), reflecting clinically significant improvements from baseline values of 17 (10 to 24), 12 (3 to 21) and 12 (3 to 20) respectively. Severe symptoms were uncommon (affected less than 5 per cent of patients) for most patient‐reported outcome scales or items, but persistent severe symptoms were noted for sexual function (2 per cent increase from baseline), peripheral neuropathy (2 per cent increase), constipation (10 per cent increase) and diarrhoea (5 per cent increase).
Long‐term survivors of metastatic colorectal cancer who have undergone liver surgery have excellent global quality of life, high levels of function and few symptoms.Full text