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Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm. BJS 2008; 95: 1239-1244.

Published: 2nd September 2008

Authors: L. Smallwood, R. Allcock, F. van Bockxmeer, N. Warrington, L. J. Palmer, B. Iacopetta et al.

Background

Increased matrix metalloproteinase (MMP) 9 activity has been implicated in the formation of abdominal aortic aneurysm (AAA). The aim was to explore the association between potentially functional variants of the MMP‐9 gene and AAA.

Method

The − 1562C > T and − 1811A > T variants of the MMP‐9 gene were genotyped in 678 men with an AAA (at least 30 mm in diameter) and 659 control subjects (aortic diameter 19–22 mm) recruited from a population‐based trial of screening for AAA. Levels of MMP‐9 were measured in a random subset of 300 cases and 84 controls. The association between genetic variants (including haplotypes) and AAA was assessed by multivariable logistic regression.

Results

There was no association between the MMP‐9 − 1562C > T (odds ratio (OR) 0·70 (95 per cent confidence interval (c.i.) 0·27 to 1·82)) or − 1811A > T (OR 0·71 (95 per cent c.i. 0·28 to 1·85)) genotypes, or the most common haplotype (OR 0·81 (95 per cent c.i. 0·62 to 1·05)) and AAA. The serum MMP‐9 concentration was higher in cases than controls, and in minor allele carriers in cases and controls, although the differences were not statistically significant.

Conclusion

In this study, the genetic tendency to higher levels of circulating MMP‐9 was not associated with AAA. Copyright © 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

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