Population‐based cohort study of diabetes mellitus and mortality in gastric adenocarcinoma.
Published: 27th July 2018
Authors: J. Zheng, S.‐H. Xie, G. Santoni, J. Lagergren
Gastric adenocarcinoma is a common cause of cancer death globally. It remains unclear whether coexisting diabetes mellitus influences survival in patients with this tumour. A cohort study was conducted to determine whether coexisting diabetes increases mortality in gastric adenocarcinoma.
This nationwide population‐based cohort study included all patients diagnosed with gastric adenocarcinoma in Sweden between 1990 and 2014. Cox proportional hazards regression and competing risks regression were used to assess the influence of coexisting diabetes on disease‐specific mortality in gastric adenocarcinoma with adjustment for sex, age, calendar year and co‐morbidity (Charlson Co‐morbidity Index score excluding diabetes).
Among 23 591 patients with gastric adenocarcinoma, 2806 (11·9 per cent) had coexisting diabetes. Overall, patients with diabetes had a moderately increased risk of disease‐specific mortality after diagnosis of gastric adenocarcinoma compared with those without diabetes, as shown by both Cox regression (hazard ratio (HR) 1·17, 95 per cent c.i. 1·11 to 1·22) and competing risks regression (sub‐HR 1·08, 1·02 to 1·13). The HRs for disease‐specific mortality were notably increased in diabetic patients without other co‐morbidity (HR 1·23, 1·15 to 1·32) and in diabetic patients who had surgery with curative intent (HR 1·27, 1·16 to 1·38).
These findings indicate a worse prognosis in patients with gastric adenocarcinoma and coexisting diabetes compared with those without diabetes.Full text
You may also be interested in
Meta‐analysis of the influence of lifestyle changes for preoperative weight loss on surgical outcomes.
Authors: M. Roman, A. Monaghan, G. F. Serraino, D. Miller, S. Pathak, F. Lai et al.
Notes: Possible but how much is enough?
Multicentre cohort study of antihypertensive and lipid‐lowering therapy cessation after bariatric surgery.
Authors: J. Thereaux, T. Lesuffleur, S. Czernichow, A. Basdevant, S. Msika, D. Nocca et al.
Notes: Better than controls
Authors: M. S. de Vos, J. F. Hamming
Development and validation of a nomogram to predict recurrence and melanoma‐specific mortality in patients with negative sentinel lymph nodes.
Authors: D. Verver, D. van Klaveren, V. Franke, A. C. J. van Akkooi, P. Rutkowski, U. Keilholz et al.
Notes: Could personalize care
Authors: A. M. Warwick, T. Jenks, R. Fisher, R. Garrett‐Cox, F. Lecky, D. Yates et al.
Notes: Better in hospitals with a paediatric surgeon
Experimental study of needle recording electrodes placed on the thyroid cartilage for neuromonitoring during thyroid surgery.
Authors: Y. Zhao, C. Li, D. Zhang, L. Zhou, X. Liu, S. Li et al.
Notes: Quick and stable
Authors: D. J. Harris, S. J. Vine, M. R. Wilson, J. S. McGrath, M.‐E. LeBel, G. Buckingham et al.
Notes: Watching other surgeons helpful
Authors: A. Storesund, A. S. Haugen, M. Hjortås, M. W. Nortvedt, H. Flaatten, G. E. Eide et al.
Notes: Code correctly
Authors: O. Uleberg, K. Pape, T. Kristiansen, P. R. Romundstad, P. Klepstad
Authors: G. Polychronidis, F. J. Hüttner, P. Contin, K. Goossen, L. Uhlmann, M. Heidmann et al.