Quality of life in a randomized trial of early closure of temporary ileostomy after rectal resection for cancer (EASY trial). BJS 2018; 105: 244-251.
Published: 23rd November 2017
Authors: J. Park, A. K. Danielsen, E. Angenete, D. Bock, A. C. Marinez, E. Haglind et al.
A temporary ileostomy may reduce symptoms from anastomotic leakage after rectal cancer resection. Earlier results of the EASY trial showed that early closure of the temporary ileostomy was associated with significantly fewer postoperative complications. The aim of the present study was to compare health‐related quality of life (HRQOL) following early
Early closure of a temporary ileostomy (at 8–13 days) was compared with late closure (at more than 12 weeks) in a multicentre RCT (EASY) that included patients who underwent rectal resection for cancer. Inclusion of participants was made after index surgery. Exclusion criteria were signs of anastomotic leakage, diabetes mellitus, steroid treatment, and signs of postoperative complications at clinical evaluation 1–4 days after rectal resection. HRQOL was evaluated at 3, 6 and 12 months after resection using the European Organisation for Research and Treatment of Cancer (EORTC) questionnaires QLQ‐C30 and QLQ‐CR29 and Short Form 36 (SF‐36®).
There were 112 patients available for analysis. Response rates of the questionnaires were 82–95 per cent, except for EORTC QLQ‐C30 at 12 months, to which only 54–55 per cent of the patients responded owing to an error in questionnaire distribution. There were no clinically significant differences in any questionnaire scores between the groups at 3, 6 or 12 months.
Although the randomized study found that early closure of the temporary ileostomy was associated with significantly fewer complications, this clinical advantage had no effect on the patients' HRQOL. Registration number: NCT01287637 (
You may also be interested in
Authors: S. Yamashita, Y. S. Chun, S. E. Kopetz, J.‐N. Vauthey
Notes: Molecular influences on outcome
Serum carcinoembryonic antigen trends for diagnosing colorectal cancer recurrence in the FACS randomized clinical trial. BJS 2018; 105: 658-662.
Authors: B. Shinkins, J. N. Primrose, S. A. Pugh, B. D. Nicholson, R. Perera, T. James et al.
Notes: Not good enough alone
Multicentre study of laparoscopic or open assessment of the peritoneal cancer index (BIG‐RENAPE). BJS 2018; 105: 663-667.
Authors: G. Passot, F. Dumont, D. Goéré, C. Arvieux, P. Rousset, J.‐M. Regimbeau et al.
Notes: Underestimated by laparoscopy
Factors affecting outcomes following pelvic exenteration for locally recurrent rectal cancer. BJS 2018; 105: 650-657.
Authors: M.E. Kelly, R. Glynn, A.G.J. Aalbers, M. Abraham‐Nordling, W. Alberda, A. Antoniou et al.
Notes: Complete resection is key
Randomized clinical trial
Randomized clinical trial of intracutaneously versus transcutaneously sutured ileostomy to prevent stoma‐related complications (ISI trial). BJS 2018; 105: 637-644.
Authors: M. F. Sier, D. D. Wisselink, D. T. Ubbink, R. J. Oostenbroek, G. J. Veldink, B. Lamme et al.
Notes: More leaks with intracutaneous
Authors: S. J. Chapman, A. Pericleous, C. Downey, D. G. Jayne
Notes: No easy answers.
Randomized clinical trial
Authors: E. M. de Leede, N. J. van Leersum, H. M. Kroon, V. van Weel, J. R. M. van der Sijp, B. A. Bonsing et al.
Notes: Chewing gum no effect on recovery
Authors: E. J. Ryan, E. M. Creagh
Effect of Akt activation and experimental pharmacological inhibition on responses to neoadjuvant chemoradiotherapy in rectal cancer. BJS 2018; 105: e192-e203.
Authors: F. C. Koyama, C. M. Lopes Ramos, F. Ledesma, V. A. F. Alves, J. M. Fernandes, B. B. Vailati et al.
Notes: Molecular enhancement of treatment
Clinicopathological, genomic and immunological factors in colorectal cancer prognosis. BJS 2018; 105: e99-e109.
Authors: K. M. Marks, N. P. West, E. Morris, P. Quirke
Notes: Defines modern practice
Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery. BJS 2018; 105: e131-e141.
Authors: S. Gaines, C. Shao, N. Hyman, J. C. Alverdy
Notes: A neglected frontier
Circulating tumour cells and DNA as liquid biopsies in gastrointestinal cancer. BJS 2018; 105: e110-e120.
Authors: O. Nordgård, K. Tjensvoll, B. Gilje, K. Søreide
Notes: The inner space frontier