Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis. BJS 2017; 104: 1785-1790.
Published: 19th September 2017
Authors: H. C. Park, M. J. Kim, B. H. Lee
Uncomplicated appendicitis may resolve spontaneously or require treatment with antibiotics or appendicectomy. The aim of this randomized trial was to compare the outcome of a non‐antibiotic management strategy with that of antibiotic therapy in uncomplicated appendicitis.
Patients presenting to a university teaching hospital with CT‐verified uncomplicated simple appendicitis (appendiceal diameter no larger than 11 mm and without any signs of perforation) were randomized to management with a no‐antibiotic regimen with supportive care (intravenous fluids, analgesia and antipyretics as necessary) or a 4‐day course of antibiotics with supportive care. The primary endpoint was rate of total treatment failure, defined as initial treatment failure within 1 month and recurrence of appendicitis during the follow‐up period.
Some 245 patients were randomized within the trial, and followed up for a median of 19 months. The duration of hospital stay was shorter (mean 3·1
Treatment failure rates in patients presenting with CT‐confirmed uncomplicated appendicitis appeared similar among those receiving supportive care with either a no‐antibiotic regimen or a 4‐day course of antibiotics. Registration number: KCT0000124 (
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