Randomized clinical trial of mechanochemical and endovenous thermal ablation of great saphenous varicose veins. BJS 2019; 106: 548-554.
Published: 25th March 2019
Authors: S. Vähäaho, O. Mahmoud, K. Halmesmäki, A. Albäck, K. Noronen, P. Vikatmaa et al.
A variety of minimally invasive techniques are available for the treatment of varicose great saphenous vein (GSVs). Non‐tumescent, non‐thermal ablation methods have been developed. This study compared mechanochemical ablation (MOCA), a non‐tumescent, non‐thermal ablation technique, with two endovenous thermal ablation methods requiring tumescence in an RCT.
Patients with GSV reflux were randomized to undergo MOCA, or thermal ablation with endovenous laser (EVLA) or radiofrequency (RFA). The primary outcome measure was the occlusion rate of the GSV at 1 year.
The study finally included 125 patients, of whom 117 (93·6 per cent) attended 1‐year follow‐up. At 1 year, the treated part of the GSV was fully occluded in all patients in the EVLA and RFA groups, and in 45 of 55 in the MOCA group (occlusion rates 100, 100 and 82 per cent respectively; P = 0·002). The preoperative GSV diameter was associated with the recanalization rate of the proximal GSV in the MOCA group. At 1 year after treatment, disease‐specific life quality was similar in the three groups.
The GSV occlusion rate 1 year after treatment was significantly higher after EVLA and RFA than after MOCA. Quality of life was similar between interventions. Registration number: NCT03722134 (
You may also be interested in
Meta‐analysis of the outcomes of treatment of internal carotid artery near occlusion. BJS 2019; 106: 665-671.
Authors: A. J. A. Meershoek, E. E. Vries, D. Veen, H. M. Ruijter, G. J. Borst, A. Garcia‐Pastor et al.
Authors: S. F. Cheng, M. M. Brown, R. J. Simister, T. Richards
Baseline findings of the population‐based, randomized, multifaceted Danish cardiovascular screening trial (DANCAVAS) of men aged 65–74 years.
Authors: J. S. Lindholt, L. M. Rasmussen, R. Søgaard, J. Lambrechtsen, F. H. Steffensen, L. Frost et al.
Meta‐analysis of long‐term survival after elective endovascular or open repair of abdominal aortic aneurysm. BJS 2019; 106: 523-533.
Authors: R. M. A. Bulder, E. Bastiaannet, J. F. Hamming, J. H. N. Lindeman
Authors: D. C. Norvell, M. L. Thompson, E. J. Boyko, G. Landry, A. J. Littman, W. G. Henderson et al.
Meta‐analysis of clinical trials examining the benefit of structured home exercise in patients with peripheral artery disease. BJS 2019; 106: 319-331.
Authors: J. Golledge, T. P. Singh, C. Alahakoon, J. Pinchbeck, L. Yip, J. V. Moxon et al.
Cost‐effectiveness analysis of a randomized clinical trial of early versus deferred endovenous ablation of superficial venous reflux in patients with venous ulceration. BJS 2019; 106: 555-562.
Authors: D. M. Epstein, M. S. Gohel, F. Heatley, X. Liu, A. Bradbury, R. Bulbulia et al.
Meta‐analysis of negative pressure wound therapy of closed groin incisions in arterial surgery. BJS 2019; 106: 310-318.
Authors: R. Svensson‐Björk, M. Zarrouk, G. Asciutto, J. Hasselmann, S. Acosta
Cost‐effectiveness of targeted screening for abdominal aortic aneurysm in siblings. BJS 2019; 106: 206-216.
Authors: R. Hultgren, A. Linné, S. Svensjö
Notes: Cost effective
Influence of psoas muscle area on mortality following elective abdominal aortic aneurysm repair. BJS 2019; 106: 367-374.
Authors: M. A. Waduud, B. Wood, P. Keleabetswe, J. Manning, E. Linton, M. Drozd et al.
Systematic review of endovascular intervention and surgery for common femoral artery atherosclerotic disease. BJS 2019; 106: 13-22.
Authors: X. Jia, Z. D. Sun, J. V. Patel, K. Flood, D. D. Stocken, D. J. A. Scott et al.
Sex differences in national rates of repair of emergency abdominal aortic aneurysm. BJS 2019; 106: 82-89.
Authors: A. Aber, T. S. Tong, J. Chilcott, P. Thokala, R. Maheswaran, S. M. Thomas et al.
Notes: Why worse for women?