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Risk factors for central bile duct injury complicating partial liver resection. BJS 2012; 99: 256-262.

Published: 20th December 2011

Authors: E. A. Boonstra, M. T. de Boer, E. Sieders, P. M. J. G. Peeters, K. P. de Jong, M. J. H. Slooff et al.


Bile duct injury is a serious complication following liver resection. Few studies have differentiated between leakage from small peripheral bile ducts and central bile duct injury (CBDI), defined as an injury leading to leakage or stenosis of the common bile duct, common hepatic duct, right or left hepatic duct. This study analysed the incidence, risk factors and consequences of CBDI in liver resection.


Patients undergoing liver resection between 1990 and 2007 were included in this study. Those having resection for bile duct‐related pathology or trauma, or after liver transplantation were excluded. Characteristics and outcome variables were collected prospectively and analysed retrospectively.


There were 19 instances of CBDI in 462 liver resections (4·1 per cent). One‐third of patients with CBDI required surgical reintervention and construction of a hepaticojejunostomy. Resection type (P < 0·001), previous liver resection (P = 0·039) and intraoperative blood loss (P = 0·002) were associated with an increased risk of CBDI. Of all resection types, extended left hemihepatectomy was associated with the highest incidence of CBDI (2 of 9 procedures).


Patients undergoing extended left hemihepatectomy or repeat hepatectomy were at increased risk of CBDI. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

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