Systematic review and meta‐analysis of hypothermic machine perfusion versus static cold storage of kidney allografts on transplant outcomes. BJS 2013; 100: 991-1001.
Published: 10th June 2013
Authors: J. M. O'Callaghan, R. D. Morgan, S. R. Knight, P. J. Morris
Adequate preservation of renal allografts for transplantation is important for maintaining and improving transplant outcomes. There are two prevalent methods: hypothermic machine perfusion and static cold storage. The preferred method of storage, however, remains controversial. The objective was to review systematically the evidence comparing outcomes from these two modalities.
A literature search was performed using
Eighteen studies met the inclusion criteria, including seven
Data from the included studies suggest that hypothermic machine perfusion reduces delayed graft function compared with static cold storage. There was no difference in primary non‐function, acute rejection, long‐term renal function or patient survival. A difference in renal graft survival is uncertain.Full text
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