Ten‐year report on axillary recurrence after negative sentinel node biopsy for breast cancer from the Swedish Multicentre Cohort Study. BJS 2017; 104: 238-247.
Published: 4th January 2017
Authors: J. de Boniface, J. Frisell, L. Bergkvist, Y. Andersson
The omission of axillary lymph node dissection (ALND) in patients with breast cancer with a negative finding on sentinel node biopsy (
The Swedish Multicentre Cohort Study included 3518 women with breast cancer and a clinically negative axilla, in whom
Some 2216 sentinel node‐negative patients with 2237 breast cancers were analysed. The median follow‐up time was 126 (range 0–174) months. Isolated axillary recurrence was found in 35 patients (1·6 per cent). High histological grade and multifocal tumours were risk factors for axillary recurrence, whereas the removal of more than two sentinel nodes decreased the risk. Fourteen (40 per cent) of 35 patients died as a consequence of axillary recurrence.
The risk of axillary recurrence remains lower than expected after a negative finding on SNB at 10‐year follow‐up. Axillary recurrences may occur long after primary surgery, and lead to a significant risk of breast cancer death.Full text
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