Tryptase expression as a prognostic marker in patients with resected gastric cancer.
Published: 24th May 2017
Authors: C. Lin, H. Liu, H. Zhang, Y. Cao, R. Li, S. Wu et al.
Mast cells play important roles in the progression of various malignancies, but their prognostic value in gastric cancer is unknown. Tryptase expression, as an indicator of mast cell activity, was therefore evaluated to see whether this could be incorporated usefully into a prognostic nomogram after surgery in patients with gastric cancer.
Tissue microarrays from patients with gastric cancer were created from formalin‐fixed, paraffin‐embedded resection specimens. Tryptase density was assessed by immunohistochemistry, and the association between tryptase expression and prognosis was evaluated. Semiquantitative scoring was devised to determine an optimal cut‐off value that correlated with survival. A prognostic nomogram was then developed incorporating tryptase expression scores along with other variables known to be related to survival.
Tissue microarrays were generated from 419 patients having surgery for gastric cancer. Increased tryptase expression was associated with better overall and recurrence‐free survival (both
Tryptase expression is an independent prognostic factor for overall and recurrence‐free survival in patients with gastric cancer after surgical resection.Read more
You may also be interested in
Meta‐analysis of health‐related quality of life after minimally invasive versus open oesophagectomy for oesophageal cancer.
Authors: J. H. Kauppila, S. Xie, A. Johar, S. R. Markar, P. Lagergren
Notes: Only different in short term
Corrigendum: Metabolic nodal response as a prognostic marker after neoadjuvant therapy for oesophageal cancer. BJS 2017; 104: 947-947.
Authors: J. M. Findlay, K. M. Bradley, L. M. Wang, J. M. Franklin, E. J. Teoh, F. V. Gleeson et al.
Preoperative imaging and prediction of oesophageal conduit necrosis after oesophagectomy for cancer.
Authors: P. Lainas, D. Fuks, S. Gaujoux, Z. Machroub, A. Fregeville, T. Perniceni et al.
Notes: Vascular abnormalities may be causal
Validation of two prognostic models for recurrence and survival after radical gastrectomy for gastric cancer.
Authors: M. Bencivenga, G. Verlato, D.‐S. Han, D. Marrelli, F. Roviello, H.‐K. Yang et al.
Notes: Good performance
Survival benefit of liver resection for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma. BJS 2017; 104: 1045-1052.
Authors: H. Kim, S. W. Ahn, S. K. Hong, K. C. Yoon, H.‐S. Kim, Y. R. Choi et al.
Notes: Selected patients benefit
Authors: Z.‐X. Wang, G.‐X. Li, Z.‐W. Zhou, Z.‐P. Huang, F. Wang, R.‐H. Xu et al.
Notes: Facilitates individualized treatment
Randomized clinical trial
Randomized clinical trial of landiolol hydrochloride for the prevention of atrial fibrillation and postoperative complications after oesophagectomy for cancer. BJS 2017; 104: 1003-1009.
Authors: T. Ojima, M. Nakamori, M. Nakamura, M. Katsuda, K. Hayata, T. Kato et al.
Notes: Prevention of atrial fibrillation is beneficial
Geographic and socioeconomic factors affecting delivery of bariatric surgery across high‐ and low‐utilization healthcare systems. BJS 2017; 104: 891-897.
Authors: A. G. Doumouras, F. Saleh, A. M. Sharma, S. Anvari, S. Gmora, M. Anvari et al.
Notes: Differences between rural and urban areas
Meta‐analysis of biomarkers predicting risk of malignant progression in Barrett’s oesophagus. BJS 2017; 104: 493-502.
Authors: K. Altaf, J.‐J. Xiong, D. De la Iglesia, L. Hickey, A. Kaul
Notes: Limited clinical usefulness at present
Randomized clinical trial
Randomized clinical trial of 270° posterior versus 180° anterior partial laparoscopic fundoplication for gastro‐oesophageal reflux disease. BJS 2017; 104: 843-851.
Authors: D. J. Roks, J. H. Koetje, J. E. Oor, J. A. Broeders, V. B. Nieuwenhuijs, E. J. Hazebroek et al.
Notes: No major differences in outcomes
Locoregional relapse after gastrectomy with D2 lymphadenectomy for gastric cancer. BJS 2017; 104: 877-884.
Authors: J. S. Chang, K. H. Kim, H. I. Yoon, W. J. Hyung, S. Y. Rha, H. S. Kim et al.
Notes: Can be predicted
Outcomes of laparoscopic gastric bypass in a randomized clinical trial compared with a concurrent national database. BJS 2017; 104: 562-569.
Authors: E. Stenberg, E. Szabo, J. Ottosson, I. Näslund
Notes: Similar results demonstrating external validity