Tryptase expression as a prognostic marker in patients with resected gastric cancer. BJS 2017; 104: 1037-1044.
Published: 24th May 2017
Authors: C. Lin, H. Liu, H. Zhang, Y. Cao, R. Li, S. Wu et al.
Mast cells play important roles in the progression of various malignancies, but their prognostic value in gastric cancer is unknown. Tryptase expression, as an indicator of mast cell activity, was therefore evaluated to see whether this could be incorporated usefully into a prognostic nomogram after surgery in patients with gastric cancer.
Tissue microarrays from patients with gastric cancer were created from formalin‐fixed, paraffin‐embedded resection specimens. Tryptase density was assessed by immunohistochemistry, and the association between tryptase expression and prognosis was evaluated. Semiquantitative scoring was devised to determine an optimal cut‐off value that correlated with survival. A prognostic nomogram was then developed incorporating tryptase expression scores along with other variables known to be related to survival.
Tissue microarrays were generated from 419 patients having surgery for gastric cancer. Increased tryptase expression was associated with better overall and recurrence‐free survival (both
Tryptase expression is an independent prognostic factor for overall and recurrence‐free survival in patients with gastric cancer after surgical resection.Full text
You may also be interested in
Authors: M. T. Adil, V. Jain, F. Rashid, O. Al‐taan, D. Whitelaw, P. Jambulingam et al.
Notes: Bariatric surgery improves physical function
Authors: B.‐H. Min, M. Hong, J. H. Lee, P.‐L. Rhee, T. S. Sohn, S. Kim et al.
Nomogram to predict lymph node metastasis in patients with early oesophageal squamous cell carcinoma.
Authors: H. Zheng, H. Tang, H. Wang, Y. Fang, Y. Shen, M. Feng et al.
Notes: Selecting patients for surgery or endoscopic treatment
Predictive value of abdominal CT in evaluating internal herniation after bariatric laparoscopic Roux‐en‐Y gastric bypass.
Authors: J. C. Ederveen, M. M. G. van Berckel, S. W. Nienhuijs, R. J. P. Weber, J. Nederend
Notes: Important tool for correct diagnosis
Authors: M. Kanda, D. Shimizu, H. Tanaka, C. Tanaka, D. Kobayashi, M. Hayashi et al.
Notes: Potential target for therapy
Development and validation of a difficulty score to predict intraoperative complications during laparoscopic liver resection.
Authors: M. C. Halls, G. Berardi, F. Cipriani, L. Barkhatov, P. Lainas, S. Harris et al.
Notes: Helps improve selection for laparoscopic liver resection
Authors: D. Zeng, R. Zhou, Y. Yu, Y. Luo, J. Zhang, H. Sun et al.
Notes: Immunoscore predicts prognosis in gastric cancer
Reappraisal of classification of distal cholangiocarcinoma based on tumour depth. BJS 2018; 105: 867-875.
Authors: H. Aoyama, T. Ebata, M. Hattori, M. Takano, H. Yamamoto, M. Inoue et al.
Notes: Better for T staging
Authors: S. D. Nelen, K. Bosscha, V. E. P. P. Lemmens, H. H. Hartgrink, R. H. A. Verhoeven, J. H. W. de Wilt et al.
Notes: Age does not matter
Prediction of major complications after hepatectomy using liver stiffness values determined by magnetic resonance elastography.
Authors: N. Sato, A. Kenjo, T. Kimura, R. Okada, T. Ishigame, Y. Kofunato et al.
Notes: liver stiffness predicts complications
Nationwide trends in the incidence and outcome of patients with gastrointestinal stromal tumour in the imatinib era. BJS 2018; 105: 1020-1027.
Authors: W. T. A. van der Graaf, R. Tielen, J. J. Bonenkamp, V. Lemmens, R. H. A. Verhoeven, J. H. W. de Wilt et al.
Notes: Surgery improves survival