A meta-analysis of prophylaxis of surgical site infections with topical application of povidone iodine before primary closure. World J Surg 2019; 43: 374–384.

Published: 2nd September 2019

Authors: Lopez-Cano M, Kraft M, Cuerll A, Puig-Asensio M, Balibrea J, Armengol-Carrasco M et al.


In this analysis of 16 RCTs including 7601 procedures, iodine lavage reduced the rate of overall surgical site infection: relative risk 0.64, 95 per cent confidence interval 0.48 to 0.85, P=0.002. It was most effective in elective surgery, but the effect disappeared when RCTs of uncertain quality were excluded.

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