A systematic review and meta-analysis of total thyroidectomy versus bilateral subtotal thyroidectomy for Graves’ Disease. Surgery 2014; 155: 529-540.

Published: 5th February 2015

Authors: Feroci F, Rettori M, Borrelli A, Coppola A, Castagnoli A, Perigli G et al. et al.


Twenty-three studies were included (only four RCTs), totalling 3242 patients. Total thyroidectomy reduced the recurrence rate (odds ratio 0.1, 95 percent confidence interval 0.06 to 0.18, P<0.00001), but increased both temporary (2.7, 2.04 to 3.56) and permanent (2.91, 1.59 to 5.32) hypoparathyroidism.

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