Adjuvant chemotherapy with fluorouracil plus folinic acid versus gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 2010; 304: 1073-1081.

Published: 2nd February 2011

Authors: Neoptolemos JP, Stocken DD, Bassi C, Ghaneh P, Cunningham D, Goldstein D et al. et al.


Over one thousand patients were included and followed for a minimum of 2 years (median 34.2 months). There was no difference in median survival between the two regimens: 23.0 months with fluorouracil, 23.6 months with gemcitabine. There were fewer serious side effects with gemcitabine (7.5 vs. 14 per cent, P<0.001).

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