Adjuvant treatment of high-risk, radically resected gastric cancer patients with 5-fluorouracil, leucovorin, cisplatin, and epidoxorubicin in a randomized controlled trial. J Natl Cancer Inst 2007; 99: 601-607.

Published: 1st January 2007

Authors: Cascinu S, Labianca R, Barone C, Santoro A, Carnaghi C, Cassano A et al.


Some 400 patients were included and randomized to two different adjuvant chemotherapy regimens. There was no benefit from intensive chemotherapy (which was completed in only 9.4 per cent of patients): overall 5-year survival was 52 vs. 50 per cent, relative risk 0.95, 95 per cent confidence interval 0.7 to 1.29.


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