Cervical or thoracic anastomosis after esophagectomy for cancer: a systematic review and meta-analysis. Dig Surg 2011; 28: 29–35.

Published: 27th September 2011

Authors: Biere SSAY, Maas KW, Cuesta MA, van der Peet DL.


Four small trials of moderate quality were available for analysis (one was excluded from meta-analysis). Pulmonary complications, perioperative mortality, tumour recurrence and benign stricture formation rates were similar after the two techniques. Cervical anastomosis was associated with a higher anastomotic leak rate (odds ratio 3.43, 95 per cent confidence interval 1.09 to 10.78, P=0.03), and greater risk to the recurrent laryngeal nerve (7.14, 1.75 to 29.14, P=0.006).

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