Clopidogrel with aspirin in acute minor stroke or transient ischemic attack (CHANCE) trial. Circulation. 2015; 132: 2-3.

Published: 29th October 2015

Authors: Wang Y, Pan Y, Zhao X, Li H, Wang D, Claiborne Johnston S et al. on behalf of the CHANCE Investigators et al.


The addition of clopidogrel to aspirin for 90 days after TIA or minor stroke reduced the stroke rate at 1 year from 14 to 10.6 per cent (hazard ratio 0.78, 95 per cent confidence interval 0.65 to 0.93, P=0.006) in this multicentre study that included 5170 patients.

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