Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial. Lancet 2018; 391: 2325-2334.

Published: 22nd November 2018

Authors: Devereaux PJ, Duceppe E, Guyatt G, Tandon V, Rodseth R, Biccard BM et al.


Some 1754 patients with raised troponin levels postoperatively, indicating myocardial injury, were included. Major adverse vascular events occurred in 11 per cent on dabigatran and 15 per cent on placebo; hazard ratio 0.72, 95 per cent confidence interval 0.55 to 0.93, P=0.0115.

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