Effect of more vs less frequent follow-up testing on overall and colorectal cancer–specific mortality in patients with stage II or III colorectal cancer. The COLOFOL Randomized Clinical Trial. JAMA 2018; 319: 2095-2103.

Published: 9th August 2018

Authors: Wille-Jørgensen P, Syke I, Smedh K, Laurberg S, Nielsen DT, Petersen SH et al.


Compared to low-frequency follow-up, high-frequency follow-up did not improve outcomes in this trial that included 2509 patients. The 5-year cancer-specific mortality rate risk difference was 0.8 per cent, 95 per cent confidence interval -1.7 to 3.3 per cent; P=0.5.

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