Effect of perioperative gabapentin on postoperative pain resolution and opioid cessation in a mixed surgical cohort. A randomized clinical trial. JAMA Surg 2018; 153: 303-311.

Published: 9th August 2018

Authors: Ha J , Mackey SC, Schmidt P, McCue R, Humphreys K, Trafton J et al.


A total of 410 procedures were included. Gabapentin did not reduce the time to pain cessation (hazard ratio 1.04, 95 per cent confidence interval 0.82 to 1.33; P=0.73). It did cause a small reduction in opioid use.

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