Effect of tight control management on Crohn’s disease (CALM): a multicentre, randomised, controlled phase 3 trial. Lancet 2017; 390: 2779-2789.

Published: 22nd February 2018

Authors: Colombel J-F, Panaccione R, Bossuyt P, Lukas M, Baert F, Vaňásek T et al.


Some 244 patients were included. Those randomized to tight control were more likely to reach the primary endpoint (mucosal healing and no deep ulcers) at six months: 46 versus 30 per cent in the standard clinical management group (P=0.01).

Pubmed Link

Your comments