Effects of pentoxifylline on liver regeneration: a double blinded, randomized clinical trial in 101 patients undergoing major liver resection. Ann Surg 2010; 252: 813-822.

Published: 14th March 2011

Authors: Petrowsky H, Breitenstein S, Slankamenac K, Vetter D, Lechmann K, Heinrich S et al. et al.


The study comprised 101 patients undergoing liver resection who were randomly allocated intravenous pentoxifylline starting 12h preoperatively and continuing for 72h. Liver regeneration was improved for small remnant livers (<1.2 per cent remnant:body weight ratio), but not larger ones. Clinical outcomes were similar between the groups.

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