Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA 2018; 320: 1259-1265.
Published: 19th December 2018
Authors: Salminen P, Hannu Paajanen T, Rautio T, Nordström P, Aarnio M, Rantanen T et al.
After 5 years, the cumulative risk of recurrent appendicitis was 39.1 per cent. Some 85/257 patients initially treated with antibiotics had undergone appendicectomy; all but seven had confirmed appendicitis.Pubmed Link
You may also be interested in
A randomized double blinded study to determine the effectiveness of utilizing intraperitoneal bupivacaine: does it reduce postoperative opioid use following laparoscopic appendectomy? Am J Surg 2019; 217: 479-482.
Authors: Sevensma K, Schleichert T, Shwickerath C, Shoemaker A, Miller C
Comparison of superficial surgical site infection between delayed primary versus primary wound closure in complicated appendicitis: a randomized controlled trial. Ann Surg 2018; 267: 631-637.
Authors: Siribumrungwong B, Chantip A, Noorit P, Wilasrusmee C, Ungpinitpong W, Chotiya P et al.
Optimal stump management in laparoscopic appendectomy: a network meta-analysis by the Minimally Invasive Surgery Synthesis of Interventions and Outcomes Network. Surgery 2017: 162: 994-1005.
Authors: Antoniou SA, Mavridis D, Hajibandeh S, Antoniou GA, Gorter R, Tenhagen M et al.
Antibiotics versus surgical therapy for uncomplicated appendicitis: systematic review and meta-analysis of controlled trials (PROSPERO 2015: CRD42015016882). Ann Surg 2017; 265: 889-900.
Authors: Harnoss J, Zelienka I, Probst P, Grummich K, Müller-Lantzsch C, Harnoss J et al.
Appendectomy skin closure technique, randomized controlled trial: changing paradigms (ASC). World J Surg 2016; 40: 2603–2610.
Authors: Andrade LAM, Munoz FYP, Baez MVJ, Collazos SS, Ferretiz MAM, Ruiz B et al.
Antibiotics versus appendicectomy for the treatment of uncomplicated acute appendicitis: an updated meta-analysis of randomised controlled trials. World J Surg 2016; 40: 2305–2318.
Authors: Rollins K, Varadhan KK, Neal KR, Lobo DN
Saline vs tissue plasminogen activator irrigations after drain placement for appendicitis-associated abscess: a prospective randomized trial. J Am Coll Surg 2015; 221: 390–396.
Authors: St Peter SD, Shah SR, Adibe OO, Sharp SW, Reading B, Cully B et al. et al.
Laparoscopic surgery or conservative treatment for appendiceal abscess in adults? A randomized controlled trial. Ann Surg 2015; 262: 237–242.
Authors: Mentula P, Sammalkorpi H, Leppäniemi A
Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis. The APPAC randomized clinical trial. JAMA. 2015; 313: 2340-2348.
Authors: Salminen P, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T et al. et al.
Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children: a pilot randomized controlled trial. Ann Surg 2015; 261: 67-71.
Authors: Svensson J, Patkova B, Almström M, Naji H, Hall NJ, Eaton S et al. et al.
Meta-analysis of randomized trials on single incision laparoscopic versus conventional laparoscopic appendectomy. Am J Surg 2014; 207: 613-622.
Authors: Antoniou SA, Koch OO, Antoniou GA, Lasithiotakis K, Chalkiadakis GE, Pointer R et al. et al.
Systematic review and meta-analysis of randomized controlled trials comparing single incision versus conventional laparoscopic appendectomy. World J Surg 2014; 38: 1937-1946.
Authors: Clerveus M, Morandeira-Rivas A, Moreno-Sanz C, Herrero-Bogajo ML, Picazo-Yeste JS, Tadeo-Ruiz G et al.