Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA 2018; 320: 1259-1265.

Published: 19th December 2018

Authors: Salminen P, Hannu Paajanen T, Rautio T, Nordström P, Aarnio M, Rantanen T et al.


After 5 years, the cumulative risk of recurrent appendicitis was 39.1 per cent. Some 85/257 patients initially treated with antibiotics had undergone appendicectomy; all but seven had confirmed appendicitis.

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