Methylene blue intra-arterial staining of resected colorectal cancer specimens improves accuracy of nodal staging: A randomized controlled trial. Eur J Surg Oncol 2016; 42: 1642–1646.

Published: 30th March 2017

Authors: Reima H, Saar H, Innos K, Soplepmann J


The study included 266 colorectal cancer specimens. Methylene blue injection into the specimen after removal increased the median number of lymph nodes harvested for pathology to 27 compared with 16 in the no dye group, P<0.001. The proportion with metastatic nodes was similar: 42 versus 43 per cent.

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