Optimal antiplatelet therapy in moderate to severe asymptomatic carotid stenosis: a comprehensive review of the literature. Eur J Vasc Endovasc Surg 2019; 57: 199-211.
Published: 2nd August 2019
Authors: Murphy SJ, Naylor AR, Ricco J-B, Sillesen H, Kakkos S, Halliday H et al.
A total of 25 RCTs were included. Even though a single RCT showed no benefit, the authors argue low dose aspirin is worthwhile in asymptomatic stenosis. The same is recommended, with better evidence in patients undergoing endarterectomy or endovascular therapy. There is insufficient evidence to recommend dual antiplatelet therapy in patients with symptomatic moderate to severe carotid stenosis.Pubmed Link
You may also be interested in
Antiplatelet therapy vs anticoagulation therapy in cervical artery dissection. The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial final results. JAMA Neurol 2019; 76: 657-664.
Authors: Markus HS, Levi C, King A, Madigan J, Norris J, et al. for the et al.
A meta-analysis of randomized trials comparing bovine pericardium and other patch materials for carotid endarterectomy. J Vasc Surg 2018; 68: 1241–1256.
Authors: Texakalidis P, Giannopoulos S, Charisis N, Giannopoulos S, Karasavvidis T, Koullias G et al.
Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high-risk transient ischaemic attack. BMJ 2018; 363: k5108.
Authors: Hao Q, Tampi M, O’Donnell M, Foroutan F, Siemieniuk RAC, Guyatt G et al.
Safety of stenting and endarterectomy for asymptomatic carotid artery stenosis: a meta-analysis of randomised controlled trials. Eur J Vasc Endovasc Surg 2018; 55: 614-624.
Authors: Cui L, Han Y, Zhang S, Liu X, Zhang J
Safety and efficacy of remote ischemic preconditioning in patients with severe carotid artery stenosis before carotid artery stenting. A proof-of-concept, randomized controlled trial. Circulation 2017; 135: 1325-1335.
Authors: Zhao W, Meng R, Ma C, Hou B, Jiao L, Zhu F et al.
Association between age and risk of stroke or death from carotid endarterectomy and carotid stenting: a meta-analysis of pooled patient data from four randomised trials. Lancet 2016; 387: 1305-1311.
Authors: Howard G, Roubin GS, Jansen O, Hendrikse J, Halliday A, Fraedrich G et al.
Long-term results of stenting versus endarterectomy for carotid artery stenosis. N Engl J Med 2016; 374: 1021-1031.
Authors: Brott TG, Howard G, Roubin GS, Meschia JF, Mackey A, Brooks W et al.
Randomized trial of stent versus surgery for asymptomatic carotid stenosis. N Engl J Med 2016; 374: 1011-1020.
Authors: Rosenfield K, Matsumura JS, Chaturvedi S, Riles T, Ansel GM, Metzger C et al.
Authors: Kernan WN, Viscoli CM, Furie KM, Young LH, Inzucchi SE, Gorman M et al.
Clopidogrel with aspirin in acute minor stroke or transient ischemic attack (CHANCE) trial. Circulation. 2015; 132: 2-3.
Authors: Wang Y, Pan Y, Zhao X, Li H, Wang D, Claiborne Johnston S et al. on behalf of the CHANCE Investigators et al.
Long term results from a randomized controlled trial analyzing the role of systematic preoperative coronary angiography before elective carotid endarterectomy in patients with asymptomatic coronary artery disease. Eur J Vasc Endovasc Surg 2015; 49: 366-374.
Authors: Illuminati G, Schneider F, Greco C, Mangieri E, Schiariti M, Tanzilli G et al. et al.
Long-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: the International Carotid Stenting Study (ICSS) randomised trial. Lancet 2015; 385: 529–538.
Authors: Bonati LH, Dobson J, Featherstone RL, Ederle J, van der Worp HB, de Borst GJ et al. et al.