Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for respectable liver metastases from colorectal cancer (EORTC Intergroup Trial 40983): a randomised controlled trial. Lancet 2008; 371: 1007-1016.

Published: 1st January 2008

Authors: Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P et al.


A total of 364 patients with up to four liver metastases were randomly allocated six cycles of chemotherapy before, and six cycles after their liver surgery. After three years, progression-free survival was improved in the chemotherapy group: 35.4 vs. 28.1 per cent, P=0.058.


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