Probiotic prophylaxis in predicted severe pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 2008; 371: 651-659.

Published: 1st January 2008

Authors: Besselink MGH, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM et al.


The study included 298 participants. Probiotic prophylaxis did not reduce the rate of infectious complications (30 per cent vs. 28 per cent in controls). Probiotics appeared to increase the mortality rate 24 vs. 9 (relative risk 2.53, 95 per cent confidence interval 1.22 to 5.25), particularly from bowel ischaemia.


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