Prospective randomized double-blinded trial comparing 2 anti-MRSA agents with supplemental coverage of cefazolin before lower extremity revascularization. Ann Surg 2015; 262: 495–501.

Published: 15th December 2015

Authors: Stone P, AbuRahma, AF, Campbell JR, Hass S, Mousa AY et al.


The study included 178 patients undergoing bypass surgery. The addition of either vancomycin or daptomycin to standard cephalosporin prophylaxis had a similar effect: surgical site infection rates 8.2 and 11.8 respectively. Vancomycin appeared to reduce the rate of Gram positive bacterial infections.

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