Randomized phase 3 trial comparing preoperative and postoperative chemoradiotherapy with capecitabine for locally advanced rectal cancer. Cancer 2011; 117: 3703–3712.

Published: 21st February 2012

Authors: Park JH, Yoon SM, Yu CS, Kim JH, Kim TW, Kim JC et al.


After median follow-up of 52 months, overall and disease-free survival rates were similar in this study that included 240 patients. Patients with low rectal tumours had a higher rate of sphincter preservation (68 vs. 42 per cent, P=0.008) if adjuvant treatment was preoperative.

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