Restrictive strategy versus usual care for cholecystectomy in patients with gallstones and abdominal pain (SECURE): a multicentre, randomised, parallel arm, non-inferiority trial. Lancet 2019; 393: 2322-2330.

Published: 2nd August 2019

Authors: Van Dijk AH, Wennmacker SZ, de Reuver PR, Latenstein CS, Buyne O, Donkervoort SC et al.

Conclusion

Some 1067 patients were randomized to routine care or cholecystectomy based on five specific criteria. After 12 months, there was no difference in the proportion who were pain-free between the groups (P=0.32). There were fewer cholecystectomies done in the restricted care group: 68 versus 75 per cent, P=0.01. There was no difference in the rate of gallstone-related complications.

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