Routine pre-procedural rectal indometacin versus selective post-procedural rectal indometacin to prevent pancreatitis in patients undergoing endoscopic retrograde cholangiopancreatography: a multicentre, single-blinded, randomised controlled trial. Lancet 2016; 387: 2293–2301.

Published: 7th September 2016

Authors: Luo H, Zhao L, Leung J, Zhang R, Liu Z, Wang X et al.


In this study that included 2600 procedures, routine pre-intervention indomethacin reduced the rate of pancreatitis to 4 per cent, compared to 8 per cent in patients who had the drug postoperatively selectively, depending on risk; P<0.0001.

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