Safety and efficacy of remote ischemic preconditioning in patients with severe carotid artery stenosis before carotid artery stenting. A proof-of-concept, randomized controlled trial. Circulation 2017; 135: 1325-1335.

Published: 2nd August 2017

Authors: Zhao W, Meng R, Ma C, Hou B, Jiao L, Zhu F et al.


A total of 189 patients were randomized to preconditioning, sham or control groups. The rate of new diffusion-weighted brain lesions on MRI after carotid stenting was lowest after preconditioning (15.9 per cent) compared to sham (36.5 per cent) and control groups (41.3 per cent); both P<0.01. Clinical adverse outcomes were rare, and equally distributed.

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